Switching risk and protective alleles improves Alzheimer's-disease-like signatures and disruptions in mice

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive degradation of brain cells, as well ...
GEN

Comprehensive Allele-Specific DNA Methylation Atlas Developed

Researchers have developed the first comprehensive atlas of allele-specific DNA methylation across 39 human cell types, revealing a complex landscape of epigenetic regulation. The study identified ...
Healthline

What Does It Mean to Be Homozygous?

In general, humans have the same genes. A number of genes are varied. These control our physical traits and health. Each variation is called an allele. You inherit two alleles for each gene. One comes ...
Science Daily

A single allele deletion in gene encoding Zbtb38 leads to early embryonic death

Researchers have found that heterozygous loss of the methyl-CpG binding protein Zbtb38 downregulated the expression of the transcription factors Nanog and Sox2, as well as genes involved in epiblast ...
Medical Xpress

Researchers untangle the APOE4 gene, the most significant genetic risk factor for Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some ...
KTLA

BlueAllele® Corporation continues to advance therapeutic approaches using novel gene correction technologies and secures third patent from the USPTO

OAKDALE, Minn., June 21, 2022 /PRNewswire/ -- BlueAllele® Corporation, a biotechnology company focused on advancing transformational gene correction technologies, announced today that the United ...
Science Daily

Evidence suggests bubonic plague had long-term effect on human immunity genes

Scientists examining the remains of 36 bubonic plague victims from a 16th century mass grave in Germany have found the first evidence that evolutionary adaptive processes, driven by the disease, may ...