The discovery five years ago that short interfering RNAs (siRNAs) can also silence gene expression in higher organisms has revolutionized loss-of-function genetic screens in mammalian cells 1. The use ...
Cell therapy developer Celyad Oncology is using short-hairpin RNA (shRNA) to create T cells that can be used as an “off-the-shelf” allogeneic therapy for cancer patients. They are also using the ...
The renin–angiotensin–aldosterone system (RAAS) is an endocrine system that plays an important role in the regulation of blood pressure (BP). The overactivity of the RAAS is involved in the ...
RNA interference is a biological process that has evolved with the evolution of mammals and plays an important role in transient and long-term blocking of protein expression. Short Hairpin RNA (shRNA) ...
RNA-based therapies are enjoying a renaissance, owing in part to the recent approvals of Alnylam Pharmaceuticals’ RNA interference (RNAi) drugs, Onpattro ® (patisiran) and Givlaari™ (givosiran).
Sigma-Aldrich has announced the release of the MISSION™ TRC shRNA human and mouse libraries for RNA interference-based research. The collection now carries approximately 65,000 shRNA vector constructs ...
If our TRC library does not cover the hairpin you need for your research, we can clone a custom sequence for you into the TRC library vector pLKO.1. Contact us by email if you wish to order custom ...
GBU distributes clones from the TRC1 shRNA library and the Sanger CRISPR knockout gRNA library. The clones are available as glycerol stocks, plates, DNA minipreps or midipreps. If you need virus ...
What is Short Hairpin RNA? RNA serves a wide variety of roles within a cell, carrying out catalytic, regulatory, structural and genetic transferal functions. A type of artificial RNA, called short ...
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