May 24, 2012 — Patients with acute ischemic stroke who are receiving warfarin can safely receive intravenous (IV) tissue plasminogen activator (tPA) if their international normalized ratio (INR) is ...

Use of the "clot-busting" drug tissue plasminogen activator (tPA) to treat patients with strokes caused by a blockage of blood flow nearly doubled between 2003 and 2011. A research team reports both ...

IV tissue plasminogen activator (tPA) is a safe and effective therapy for acute ischemic stroke when administered within established time windows. The main complication from administration of tPA is ...

Less than one-third of stroke patients treated with tissue plasminogen activator (tPA) received the clot-busting drug within 60 minutes or less of their arrival. A hospital arrival-to-treatment ...

Emergency mobile stroke unit. Ambulance van furnishes services to diagnose stroke patients. Two neurologists discuss the barriers to timely tPA administration in acute stroke, including the ...

Moreover, tPA has inherent neurotoxic actions that counteract some of the therapeutic benefits of the drug. Armstead et al. have found that administration of the small peptide EEIIMD with tPA reduces ...