The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score of 30-18. The Colts are currently set to enter this game as the home betting underdogs. The game will be broadcast on ESPN on Monday night.

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16

Did Cris Collinsworth cross a line on Sunday evening? The longtime "Sunday Night Football" announcer was on the call of Sunday's game between the Dallas Cowboys and the Minnesota Vikings. The Vikings topped the Cowboys,

The TV broadcast map has been released, and with the Ravens on NBC Sunday Night Football, the Saturday and Sunday slate offers huge games with playoff impact

The Seahawks not only clinched a spot in the postseason with their OT win Thursday over the Rams, but their quest to win the NFC West and get the No. 1 seed is in their sights.

Every week for the duration of the 2025 regular season , USA TODAY Sports will provide timely updates to the NFL 's ever-evolving playoff picture − typically starting Sunday afternoon and then moving forward for the remainder of the week (through Monday's and Thursday's games or Saturday's,

Oklahoma 8 p.m., ABC/ESPN This is shaping up as a low-scoring affair, with both offenses on the decline as defenses figured out how to slow them down with each passing week. However, it should be the most electric atmosphere of the first round with a frenzied Sooner fanbase ecstatic to be back