A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Respiratory infections are among the leading causes of illness and death in the elderly, driven by immune aging, chronic ...

The lack of animal models that mimic human disease impedes the study of many pathologies that still lack treatment beyond symptom relief. This is what has happened so far with PURA syndrome, a rare ...

Although periodontitis is an extremely prevalent disorder, it is challenging to conduct detailed and comprehensive analyses of its progression at the cellular level. Recently, researchers developed an ...

Animal models are established, important tools for preclinical safety and efficacy testing. Companies are advancing more “humanized” models to better reflect human responses, while at the same time ...

An article by Gina Kolata in the February 11 New York Times titled “Mice Fall Short as Test Subjects for Some of Humans’ Deadly Ills,” unleashed a maelstrom—from both those advocating alternatives to ...

The Food and Drug Administration and National Institutes of Health held a joint workshop July 7 on reducing animal testing in research, strikingly announcing that “NIH will no longer seek proposals ...

This year could mark a turning point for one of science’s most familiar animals: the laboratory mouse. For decades, mice and ...

Cannabidiol (CBD) could become a therapeutic tool to address some of the most frequent and disabling consequences of fetal ...