Clinical activity with anti–CTLA-4 monoclonal antibodies (mAbs) has paved the way for additional T-cell immunomodulatory monoclonal antibody (mAb) approaches for the treatment of cancer to be ...

DURING the course of an investigation 1 into the function and life-cycle of lymphocytes, a number of physical techniques were employed to determine the identity of cells isolated from various sources, ...

Researchers have identified a promising new weapon against triple-negative breast cancer, one of the most aggressive forms of ...

Antibodies are Y-shaped protective proteins manufactured by B lymphocytes in reaction to invading pathogens. When B lymphocytes encounter foreign antigens expressed by antigen-presenting cells (e.g.

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking ...

In the present study, we investigated the tuberculosis (TB) diagnostic performance of an assay on the basis of detection of TB-specific antibodies from peripheral blood mononuclear cells (PBMCs), to ...

Infection by live attenuated retroviruses provides excellent protection from challenge with pathogenic viruses in several animal models, but little is known about which immune effectors are necessary ...

Developed by Genentech/IDEC, Rituxan® (rituximab) is a genetically engineered molecule derived from a mouse antibody designed to kill B lymphocytes. B lymphocytes, or B cells, are the white blood ...

Since the late 1990s, immunotherapy has been the frontline treatment against lymphomas where synthetic antibodies are used to stop the proliferation of cancerous white blood cells. However, in the ...

Antigens are detected by lymphocytes. Each lymphocyte has several antibodies which can be thought of as detectors. Each antibody is specific to a particular antigen. Typically, because ...

Transfusion Alter Transfusion Med. 2008;10(3):112-126. There is no diagnostic test or pathognomonic finding for TRALI, so the diagnosis is one of exclusion. Other causes of respiratory distress and ...