An otherwise healthy 42-year-old man presented with a small erythematous nodule on the superior part of his right ear and substantial swelling of the entire pinna (Figure 1A), which he had first ...

Leishmaniasis is a parasitic disease that affects up to 1 million people worldwide each year. It is caused by the protozoan Leishmania, transmitted through the bite of a sandfly. Once inside its ...

Researchers have taken an important step forward in developing a controlled human infection model to test leishmaniasis vaccines. Researchers have taken an important step forward in developing a ...

Visceral leishmaniasis (VL) is a systemic protozoan disease that is transmitted by phlebotomine sandflies. Poor and neglected populations in East Africa and the Indian sub-continent are particularly ...

Scientists have developed a new, safe and effective way to infect volunteers with the parasite that causes leishmaniasis and measure the body's immune response, bringing a vaccine for the neglected ...

According to the World Health Organization (WHO), the parasites are spread by sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World. At least 93 sandfly ...

Some leishmaniasis drugs are exceedingly expensive, placing a significant load on public health systems, and if administered incorrectly, they can trigger drug resistance in the parasite. As a result, ...

Leishmaniasis, transmitted by a sandfly bite, causes 500,000 cases of visceral disease and 1.5 million cases of cutaneous disease – resulting in 50,000 deaths annually. The drugs to treat it are ...

At first look, three particular tropical diseases could seem unrelated. They affect millions of people worldwide, but in much different ways. One can cause cardiac arrest in 30% of people infected, ...

Nobody wants to get bitten by a sandfly and catch a terrible disease with a daunting name – visceral leishmaniasis. It can cause fever, weight loss, enlargement of the spleen and liver, and anemia. If ...

Susceptibility to leishmaniasis is influenced by multiple host genes, most of which are low-penetrance QTLs. They have been difficult to map in humans because of their number, the genetic ...

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