Cytoplasmic dynein is a motor protein that walks along microtubules (MTs) and performs mechanical work to power a variety of cellular processes. It remains unclear how a dynein dimer is able to ...

Dr. Jonas Wilson, MD, Ing. Med. Dynein, one of three cytoskeletal motor protein families, was first identified a half century ago and got its name after the ‘dyne’ (i.e. a unit of force). Motor ...

Intracellular protein aggregation is a common theme in neurodegenerative disease. The formation of aggregates is blamed on protein overproduction, a failure of clearance, or both. Score one for the ...

What is the dynein-dynactin complex and where is it found? What functions is this molecular motor thought to perform within cells? This is a macromolecular assembly is made up of two components, ...

Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to carting protein instructions to disposing of cellular garbage. These highways ...

A mechanism of dynein-powered metastatic locomotion has been identified using soft tissue models, revealing a new clinical target for breast cancer treatment. New research led by Penn State (PA, USA) ...

The motor protein dynein, which carries molecular cargo along microtubule tracks in cells, is less understood than other motor proteins such as kinesin and myosin. Dynein's motor region consists of a ...

Researchers have uncovered the mechanism by which a protein facilitates the spread of breast cancer cells from the primary tumor into healthy tissue. The discovery not only improves our understanding ...