The host cell system is a critical determinant of recombinant protein quality and yield, with direct influence on protein folding and post-translational modification factors that shape the ...

Production of recombinant monoclonal antibodies (mAbs) for therapeutic use is a multibillion dollar industry. At present, mammalian cell lines are the workhorses of the biotechnology industry, due to ...

A study published in the Proceedings of the National Academy of Sciences has uncovered new clues to why some therapeutic proteins are so difficult to manufacture. The work—led by Nathan Lewis, PhD, ...